Endocrine Abstracts

Proliferative inflammatory atrophy and prostatic intraepithelial neoplasia are the first signs of prostate cancer. This inflammatory etiology, together with the infiltration of immune cells, could lead to the binding of the cytokines with cancer cells, forming a population that could initiate tumor growth. [1] Androgens also play an essential role in prostate tumor growth, as is well documented. [2] Androgen deprivation therapy is currently the gold standard for hormone-sensit...

Benign prostatic hyperplasia and prostate cancer are androgen-dependent diseases. Dihydrotestosterone (DHT) is a 5α-reduced metabolite of testosterone (T), which is the causative factor for the progression of these diseases. The 5α-reductase enzyme (5α-R) converts T to DHT, which is responsible for increasing cell proliferation, and hence inhibition of this enzyme could lead to potential treatments for these afflictions. This study aimed to determine the biologi...